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润色:Additional, the impact of early environment on growth and development might have a long -term impact on human. A prospective cohort study strongly pointed out that H. pylori infection may hinder linear growth in preschool children26. And H. pyl...

Additionally, the impact of early environment on growth and development may have long-term effects on humans. A prospective cohort study strongly suggests that H. pylori infection may hinder linear growth in preschool children, leading to reduced absorption of important nutrients and slow growth in children, ultimately resulting in low skeletal muscle mass in elderly individuals. Ghrelin and leptin may also be factors contributing to the association between H. pylori and LSMM, as H. pylori has been shown to affect their secretion. Leptin is secreted by adipose tissue and plays a vital role in inflammation, insulin sensitivity, regulation of appetite, and fat deposition, while ghrelin can increase muscle mass through stimulating appetite, increasing food intake, promoting myocyte differentiation and fusion, among other ways. Several studies have shown decreased levels of ghrelin and leptin in patients with LSMM. Additionally, a multivariate logistic regression analysis was performed to identify risk factors related to LSMM; age, BMI, and Cre were found to be significant risk factors that supplement the current understanding of LSMM risk factors.

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