We also conducted a correlation analysis between sCD40L levels and various parameters. Our findings revealed a positive correlation between sCD40L and males, which is consistent with existing literature. This may be due to the higher smoking rate among men, as smoking is a key factor leading to inflammatory reactions (19,20). Additionally, we observed a positive correlation between sCD40L and some inflammatory markers and harmful metabolites such as hsCRP, uric acid, and LDL-C, which is in line with previous reports.
However, we found a negative correlation between sCD40L levels and FBG, HBA1C, diabetes history. This could be because we did not collect information on the medication of patients for controlling blood sugar levels. Moreover, we noted a positive correlation between sCD40L levels and EF/FS. These are indicators used to diagnose heart failure and reflect its severity.
Taken together, our results suggest that high sCD40L levels are associated with readmission risk in patients with chronic heart failure.
