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A 45-year old woman returns from a Safari trip to Africa. A few weeks later, she starts to present with severe headaches accompanied by a cough, fatigue and malaise. More importantly, the woman experiences cyclical paroxysms of fever, shaking chil...

I apologize, but I am unable to view or interpret images. However, based on the provided information, it appears to be a case of malaria.

A) The disease the woman is likely to have acquired: Malaria. B) The pathogen responsible for this disease: Plasmodium spp.

C) i) Classification of Plasmodium: Plasmodium belongs to the phylum Apicomplexa, class Sporozoa. ii) It is a unicellular organism. iii) Plasmodium belongs to the domain Eukarya.

D) The class to which this parasite belongs: The class is Aconoidasida. The classification is based on their medical importance and structural characteristics.

E) i) Hosts used by Plasmodium: Mosquitoes serve as definitive hosts, while humans are intermediate hosts. ii) Definitive hosts: Mosquitoes (specifically female Anopheles mosquitoes)

   Intermediate hosts: Humans

iii) Different reproductive strategies in different hosts:

    - Sexual reproduction occurs in mosquitoes
    - Asexual reproduction occurs in human liver cells and red blood cells

F) Stages recognized in the life cycle of Plasmodium: There are four stages recognized in the life cycle:

1. Sporozoite stage
2. Merozoite stage
3. Gametocyte stage
4. Zygote/Ookinete stage

G) i) Each stage of the pathogen’s life cycle:

   - Sporozoite stage: Found in mosquito saliva after transmission; invades liver cells upon entering human host.
   - Merozoite stage: Released from infected liver cells; invades red blood cells (RBCs).
   - Gametocyte stage: Sexual forms produced within RBCs; taken up by mosquitoes during blood feeding.
   - Zygote/Ookinete stage: Forms in mosquito midgut after fertilization; develops into oocysts.

ii) Developmental stages found in each stage:

   - Sporozoite stage: Sporozoites
   - Merozoite stage: Merozoites
   - Gametocyte stage: Male and female gametocytes
   - Zygote/Ookinete stage: Zygotes and ookinetes

iii) Host for each stage:

   - Sporozoite stage: Mosquito (vector)
   - Merozoite stage: Human
   - Gametocyte stage: Human
   - Zygote/Ookinete stage: Mosquito (definitive host)

H) i) How the woman has probably acquired the infection: Through the bite of an infected mosquito. ii) Type of transmission: Vector-borne transmission. iii) Preventive measures that can be adopted:

    - Using mosquito nets or bed nets treated with insecticides to prevent mosquito bites during sleep.
    - Applying insect repellents on exposed skin surfaces.
    - Eliminating stagnant water sources to reduce mosquito breeding grounds.

I) To make a definite diagnosis of malaria, various methods can be used, including:

  • Microscopic examination of blood smears to identify the presence of Plasmodium parasites in red blood cells.
  • Rapid diagnostic tests (RDTs) that detect specific antigens produced by Plasmodium parasites in blood samples.
  • Molecular techniques like polymerase chain reaction (PCR) for accurate species identification and detection of low-level infections.


    内容由零声教学AI助手提供,问题来源于学员提问

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