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According to the results of the analysis, the following new generation BTKi-based therapy conditions yielded higher efficacy: < 65 years old, TN-CLL, and BTKi combination therapy. Su-bgroup analysis showed that the OR and CR rates from acalabrutin

Furthermore, the analysis showed that patients with del(17p) or TP53 mutations had lower response rates to BTKi therapy, indicating that alternative treatment strategies may need to be considered for these patients. Overall, the results of this analysis suggest that age, disease subtype, and combination therapy with BTKi and chemotherapy should be taken into consideration when selecting treatment options for CLL patients. Additionally, zanubrutinib may be preferred over acalabrutinib for monotherapy in CLL patients.

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