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Case presentation Robin, a 54-year-old widower, who lived alone, was admitted to hospital after his son found him semiconscious at home. Robin had seemed well when he visited him one week earlier, but he recalled that Robin had been complaining of...

  1. The most likely cause of the high Osmolality in this case is C. DKA (Diabetic Ketoacidosis).

Rationale: DKA is a condition characterized by elevated blood glucose levels and ketone production. It leads to an increase in serum osmolality due to the presence of ketones, which are osmotically active particles.

  1. The treatment that should be prioritized as part of the emergency intervention for the patient is B. Insulin to lower blood glucose.

Rationale: In DKA, insulin deficiency leads to uncontrolled hyperglycemia. Administration of insulin helps lower blood glucose levels and reverses the metabolic derangements associated with DKA.

  1. i. Differential diagnosis of Robin’s test results:
  • High Urea: Elevated urea may be seen in conditions like renal failure, dehydration, excessive protein breakdown (e.g., catabolic state), or increased protein intake.
  • High Na+: Hypernatremia can occur due to water deficit relative to sodium excess or loss.
  • Normal K+: Potassium levels within the reference range suggest no major abnormalities related to potassium balance.
  • High Glucose: Severe hyperglycemia indicates uncontrolled diabetes.
  • Low Bicarbonate: Decreased bicarbonate levels suggest metabolic acidosis.

ii. To confirm the diagnosis, additional tests that could be ordered include:

  • Hemoglobin A1c (HbA1c): It provides information about long-term glycemic control and helps diagnose underlying diabetes.
  • Urine Ketones: Presence of ketones in urine confirms the ketotic state associated with DKA.
  1. i. Based on the diagnosis of DKA, recommendations for Robin to better manage his disorder would include:
  • Diabetes Education: Provide education on self-monitoring of blood glucose, insulin administration techniques, recognizing signs and symptoms of hypo/hyperglycemia, and lifestyle modifications (diet, exercise).
  • Regular Medical Follow-up: Schedule regular visits to monitor glycemic control, adjust insulin therapy as needed, and assess for any complications.
  • Blood Glucose Monitoring: Emphasize the importance of regular blood glucose monitoring to maintain tight glycemic control.

ii. It would be advisable to suggest Robin’s son get tested for diabetes or undergo a medical evaluation based on family history and potential risk factors.

Rationale: Diabetes can have a genetic component, and individuals with a family history of diabetes may have an increased risk. Therefore, it would be prudent to assess the son’s risk and initiate appropriate screening or evaluation if indicated.


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