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According to the results of the analysis, the following new generation BTKi-based therapy conditions yielded higher efficacy: < 65 years old, TN-CLL, and BTKi combination therapy. Su-bgroup analysis showed that the OR and CR rates from acalabrutin

Overall, the analysis suggests that BTKi-based therapy is highly effective for treating CLL and CNSL. The specific conditions that lead to higher efficacy include being under 65 years old, having TN-CLL, and receiving combination therapy with acalabrutinib and chemotherapy. For CNSL, both acalabrutinib and zanubrutinib monotherapy are highly effective, but zanubrutinib may be the preferred option for CLL treatment. These findings provide valuable insights for clinicians in selecting optimal treatment strategies for their patients with CLL or CNSL.

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