Difference between primordial follicle and primary follicle-Go服务器开发

The main difference between a primordial follicle and a primary follicle lies in their developmental stages and characteristics. Here are the key distinctions:

Developmental Stage: Primordial follicles are in an early stage of development, while primary follicles are more advanced.
Oocyte Size: In primordial follicles, the oocyte is relatively small and surrounded by a single layer of squamous-like granulosa cells. In contrast, primary follicles have a larger oocyte and multiple layers of cuboidal granulosa cells.
Zona Pellucida Formation: The zona pellucida, which is a glycoprotein-rich structure surrounding the oocyte, is absent in primordial follicles but begins to form during the transition to primary follicles.
Granulosa Cell Differentiation: Within primary follicles, the granulosa cells start differentiating into specialized types, such as mural granulosa cells on the outermost layer and cumulus granulosa cells that directly surround the oocyte.
Follicular Growth: Primordial follicles remain dormant until activated by signals for development. Primary follicles undergo growth and maturation as they progress through subsequent stages like secondary and tertiary (mature) follicles.

Overall, primordial follicles represent an early stage of ovarian development characterized by small oocytes surrounded by a single layer of flat granulosa cells. Primary follicles denote a more advanced stage with larger oocytes, multiple layers of cuboidal granulosa cells, and initiation of zona pellucida formation.

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